Reference data

Toxic doses quick reference for dogs and cats

The toxic doses this site publishes for dogs and cats: chocolate bands, allium range, grape and raisin references, and emergency numbers.

Every dose below is quoted exactly as the site's dog and cat toxicity calculators state it, in the units those pages use. This table is a reading aid for someone who already has a number in front of them; it does not work out a dose for you.

Run the arithmetic on the calculator for your animal's weight, then use this table to see where the result sits. A figure below a threshold is not a clearance, and a figure at or above one is a reason to be on the phone straight away.

Substance or exposureSpeciesDose as published on this siteNote
Chocolate (methylxanthines)DogAbout 20 mg/kg: mild signsVomiting, diarrhoea and restlessness typically begin 6–12 hours after ingestion
Chocolate (methylxanthines)Dog40–50 mg/kg: cardiotoxic rangeHeart-rhythm disturbances are likely; contact a veterinarian now
Chocolate (methylxanthines)Dog60 mg/kg and above: seizure riskSeizures are expected at this dose; get to a clinic immediately
Chocolate (methylxanthines)DogLD50 100–200 mg/kg: potentially lethalSeizures, collapse and fatal heart rhythms are reported in this range
Chocolate (methylxanthines)CatAbout 20 mg/kg mild; 40–50 mg/kg cardiotoxic; 60 mg/kg and above seizures; LD50 100–200 mg/kgThe cat calculator grades against the same Merck bands as the dog one
Milk chocolate, rule of thumbDogAbout 1 oz per lb of body weight is potentially lethalRule of thumb from the same Merck source, quoted in the dog calculator's FAQ
White chocolateDogAbout 1 mg theobromine per oz (negligible)The fat and sugar can still cause vomiting or pancreatitis in a small dog
Theobromine content used by the dog calculatorDogMilk 57, semisweet 136, dark 70–85% 227, baker's 364, cocoa powder 808 mg per ozPer-ounce content values multiplied by the amount eaten; not doses
Theobromine content used by the cat calculatorCatWhite 0.04, milk 2.3, semisweet or dark 5.5, baker's 15.5, cocoa powder 28.5 mg per gThe cat calculator measures chocolate in grams rather than ounces
Onion, raw, cooked or driedDog15–30 g/kg: reported clinical-signs range1.5–3% of body weight; about one medium onion (150 g) for a 10 kg dog
Onion, rawCatFrom about 5 g/kgThe site notes cats are affected at roughly a third of the canine dose
GarlicDog3–5× more toxic than onion (the calculator counts it at 4×)Its worked example swaps a 150 g onion for 600 g of onion-equivalent garlic; chives, leeks and shallots count too
Grapes, raisins, sultanas, Zante currantsDogMore than 1 grape or raisin per 4.5 kg (10 lb) of body weight may pose a renal riskA risk reference, not a safe line: no established safe dose exists
Grapes or raisins, lowest documented toxic doseDog0.32–0.65 oz/kgAbout 181–369 g for a 20 kg dog; case reports describe injury below this range
Xylitol in sugar-free productsDogNo numeric dose is published on this siteNamed as a cause of hypoglycaemia and liver failure; read the ingredients list

Download: Toxic doses quick reference for dogs and cats (CSV, 15 rows): the same numbers as the table, for your own spreadsheet.

If an ingestion is suspected, contact your veterinarian or an emergency poison line immediately: do not wait to do the math. The numbers in this table are for reading, not dosing, and nothing here tells you how much of anything to give. The site lists two 24/7 numbers: ASPCA Animal Poison Control Center (888) 426-4435 and Pet Poison Helpline 1-888-213-6680, both with consultation fees that may apply. Never induce vomiting at home unless a veterinary professional tells you to, and take the wrapper, the amount eaten, the weight and the time of ingestion to the clinic.

The bands are population figures from the Merck Veterinary Manual as the calculators quote them. Individual sensitivity varies, an empty stomach speeds absorption, and pre-existing heart or kidney disease lowers the margin, so treat every value here as triage rather than diagnosis. The chocolate content values are averages from USDA and FDA composition data, and real products differ from them.

Grapes and raisins have no established safe dose anywhere in this site's guidance: the per-piece figure is a risk reference and the documented range records harm that has already been seen. Xylitol appears on this site only as an ingredient to avoid, so no dose is given for it here. Onion and garlic damage arrives late, with anaemia typically showing 3–5 days after ingestion, which is why those rows end in a phone call rather than a wait.

How this table was checked

Every row was copied from the calculator page that publishes it, then checked against that page's own source line; the emergency numbers come from the same pages' callouts. The CSV download is generated from the same rows as the table above. Last verified .

Sources

Every number in the table above traces to one of these 6 references.

  1. Merck Veterinary Manual: Chocolate Toxicosis in Animals (used for: The 20, 40–50, 60 mg/kg bands and LD50 100–200 mg/kg for dogs and cats, the 1 oz per lb rule of thumb, and the theobromine content values.)
  2. Merck Veterinary Manual: Garlic and Onion (Allium spp) Toxicosis in Animals (used for: 15–30 g/kg of raw onion producing clinical signs in dogs, cats from about 5 g/kg, and garlic being 3–5× more toxic.)
  3. Merck Veterinary Manual: Grape, Raisin, and Tamarind Toxicosis in Dogs (used for: The reference of more than one grape or raisin per 4.5 kg of body weight, and kidney failure generally within 72 hours.)
  4. ASPCA Animal Poison Control Center (used for: The lowest documented toxic grape or raisin dose of 0.32–0.65 oz/kg, and the poison-control number used in the contact block.)
  5. Pet Poison Helpline (used for: The second 24/7 emergency number in the contact block, as listed on the cat chocolate toxicity calculator.)
  6. US FDA: Leave Chocolate Out of Rover's Celebrations (used for: The per-ounce theobromine content figures the dog chocolate calculator uses for each chocolate type.)
Canine and feline toxic dose comparison scale across theobromine, caffeine, allium, grapes, and acetaminophen with mild, moderate, and lethal exposure thresholds.
Emergency toxic dose threshold matrix for dogs and cats across top clinical ingestions. Mild signs begin at 20 mg/kg for theobromine and caffeine, while onions induce oxidative RBC hemolysis above 5 g/kg. In felines, acetaminophen lacks glucuronidation clearance, triggering lethal methemoglobinemia at doses as low as 10 mg/kg.
Dr. Chyrle Bonk, DVM

Dr. Chyrle Bonk, DVM: Veterinary Editor

Chyrle is a mixed-animal veterinarian in rural Idaho who has practised since 2010, with a particular emphasis on food-animal medicine and cattle alongside her companion-animal caseload. She reviews the…

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